Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation
نویسندگان
چکیده
منابع مشابه
Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation.
GMP synthetase (GMPS), a key enzyme in the purine biosynthetic pathway performs catalysis through a coordinated process across two catalytic pockets for which the mechanism remains unclear. Crystal structures of Plasmodium falciparum GMPS in conjunction with mutational and enzyme kinetic studies reported here provide evidence that an 85° rotation of the GATase domain is required for ammonia cha...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2015
ISSN: 2041-1723
DOI: 10.1038/ncomms9930